Management of Fibrosing Interstitial Lung Diseases
Identifieur interne : 000656 ( Main/Exploration ); précédent : 000655; suivant : 000657Management of Fibrosing Interstitial Lung Diseases
Auteurs : Toby M. Maher [Royaume-Uni] ; Wim Wuyts [Belgique]Source :
- Advances in Therapy [ 0741-238X ] ; 2019.
Abstract
A proportion of patients with interstitial lung diseases (ILDs), including the ILDs that are commonly associated with autoimmune diseases, develop a progressive fibrosing phenotype characterised by worsening of lung function, dyspnoea and quality of life, and early mortality. No drugs are approved for the treatment of ILDs other than idiopathic pulmonary fibrosis (IPF). At present, immunomodulatory medications are the mainstay of treatment for non-IPF ILDs. However, with the exception of systemic sclerosis-associated ILD, the evidence to suggest that immunosuppression may preserve lung function in patients with these ILDs comes only from retrospective, observational, or uncontrolled studies. In this article, we review the evidence for the treatments currently used to treat ILDs associated with autoimmune diseases and other ILDs and the ongoing trials of immunosuppressant and antifibrotic therapies in patients with these ILDs.
Url:
DOI: 10.1007/s12325-019-00992-9
PubMed: 31119691
PubMed Central: 6824393
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="Par1">A proportion of patients with interstitial lung diseases (ILDs), including the ILDs that are commonly associated with autoimmune diseases, develop a progressive fibrosing phenotype characterised by worsening of lung function, dyspnoea and quality of life, and early mortality. No drugs are approved for the treatment of ILDs other than idiopathic pulmonary fibrosis (IPF). At present, immunomodulatory medications are the mainstay of treatment for non-IPF ILDs. However, with the exception of systemic sclerosis-associated ILD, the evidence to suggest that immunosuppression may preserve lung function in patients with these ILDs comes only from retrospective, observational, or uncontrolled studies. In this article, we review the evidence for the treatments currently used to treat ILDs associated with autoimmune diseases and other ILDs and the ongoing trials of immunosuppressant and antifibrotic therapies in patients with these ILDs.</p>
<p id="Par2"><bold><italic>Funding</italic>
</bold>
: Boehringer Ingelheim.</p>
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